B vitamins

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B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism. Though these vitamins share similar names, they are chemically distinct that often coexist in the same foods. In general, dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamin supplements are referred to by the specific number or name of each vitamin: B₁ = thiamine, B₂ = riboflavin, B₃ = niacin, etc. Some are better known by name than number: niacin, pantothenic acid, biotin and folate.

Each B vitamin is either a cofactor (generally a coenzyme) for key metabolic processes or is a precursor needed to make one.

Video B vitamins

List of B vitamins

Note: other substances once thought to be vitamins were given numbers in the B-vitamin numbering scheme, but were subsequently discovered to be either not essential for life or manufactured by the body, thus not meeting the two essential qualifiers for a vitamin. See section #Related compounds for numbers 4, 8, 10, 11, and others.

Maps B vitamins

B vitamin molecular functions

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B vitamin deficiency

Several named vitamin deficiency diseases may result from the lack of sufficient B vitamins. Deficiencies of other B vitamins result in symptoms that are not part of a named deficiency disease.

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B vitamin side effects

Because water-soluble B vitamins are eliminated in the urine, taking large doses of certain B vitamins usually only produces transient side-effects. General side effects may include restlessness, nausea and insomnia. These side-effects are almost always caused by dietary supplements and not foodstuffs.

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B vitamin sources

B vitamins are found in whole unprocessed foods. Processed carbohydrates such as sugar and white flour tend to have lower B vitamin than their unprocessed counterparts. For this reason, it is required by law in many countries (including the United States) that the B vitamins thiamine, riboflavin, niacin, and folic acid be added back to white flour after processing. This is sometimes called "Enriched Flour" on food labels. B vitamins are particularly concentrated in meat such as turkey, tuna and liver. Good sources for B vitamins include legumes (pulses or beans), whole grains, potatoes, bananas, chili peppers, tempeh, nutritional yeast, brewer's yeast, and molasses. Although the yeast used to make beer results in beers being a source of B vitamins, their bioavailability ranges from poor to negative as drinking ethanol inhibits absorption of thiamine (B₁), riboflavin (B₂), niacin (B₃), biotin (B₇), and folic acid (B₉). In addition, each of the preceding studies further emphasizes that elevated consumption of beer and other alcoholic beverages results in a net deficit of those B vitamins and the health risks associated with such deficiencies.

The B₁₂ vitamin is not abundantly available from plant products, making B₁₂ deficiency a legitimate concern for vegans. Manufacturers of plant-based foods will sometimes report B₁₂ content, leading to confusion about what sources yield B₁₂. The confusion arises because the standard US Pharmacopeia (USP) method for measuring the B₁₂ content does not measure the B₁₂ directly. Instead, it measures a bacterial response to the food. Chemical variants of the B₁₂ vitamin found in plant sources are active for bacteria, but cannot be used by the human body. This same phenomenon can cause significant over-reporting of B₁₂ content in other types of foods as well.

A popular way of increasing one's vitamin B intake is through the use of dietary supplements. B vitamins are commonly added to energy drinks, many of which have been marketed with large amounts of B vitamins with claims that this will cause the consumer to "sail through your day without feeling jittery or tense." Some nutritionists have been critical of these claims, pointing out for instance that while B vitamins do "help unlock the energy in foods," most Americans acquire the necessary amounts easily in their diets.

Because they are soluble in water, excess B vitamins are generally readily excreted, although individual absorption, use and metabolism may vary..." The elderly and athletes may need to supplement their intake of B₁₂ and other B vitamins due to problems in absorption and increased needs for energy production. In cases of severe deficiency, B vitamins, especially B₁₂, may also be delivered by injection to reverse deficiencies. Both type 1 and type 2 diabetics may also be advised to supplement thiamine based on high prevalence of low plasma thiamine concentration and increased thiamine clearance associated with diabetes. Also, Vitamin B₉ (folic acid) deficiency in early embryo development has been linked to neural tube defects. Thus, women planning to become pregnant are usually encouraged to increase daily dietary folic acid intake and/or take a supplement.

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B vitamin discovery dates

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Related compounds

Many of the following substances have been referred to as vitamins as they were once believed to be vitamins. They are no longer considered as such, and the numbers that were assigned to them now form the "gaps" in the true series of B-complex vitamins described above (e.g., there is no vitamin B₄). Some of them, though not essential to humans, are essential in the diets of other organisms; others have no known nutritional value and may even be toxic under certain conditions.

• Vitamin B₄: can refer to the distinct chemicals choline, adenine, or carnitine. Choline is synthesized by the human body, but not sufficiently to maintain good health, and is now considered an essential dietary nutrient. Adenine is a nucleobase synthesized by the human body. Carnitine is an essential dietary nutrient for certain worms, but not for humans.
• Vitamin B₈: adenosine monophosphate (AMP), also known as adenylic acid. Vitamin B₈ may also refer to inositol.
• Vitamin B₁₀: para-aminobenzoic acid (pABA or PABA), a chemical component of the folate molecule produced by plants and bacteria, and found in many foods. It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions.
• Vitamin B₁₁: pteryl-hepta-glutamic acid (PHGA; chick growth factor). Vitamin Bc-conjugate was also found to be identical to PHGA.
• Vitamin B₁₃: orotic acid.
• Vitamin B₁₄: cell proliferant, anti-anemia, rat growth factor, and antitumor pterin phosphate named by Earl R. Norris. Isolated from human urine at 0.33ppm (later in blood), but later abandoned by him as further evidence did not confirm this. He also claimed this was not xanthopterin.
• Vitamin B₁₅: pangamic acid, also known as pangamate. Promoted in various forms as a dietary supplement and drug; considered unsafe and subject to seizure by the US Food and Drug Administration.
• Vitamin B₁₆: dimethylglycine (DMG) is synthesized by the human body from choline.
• Vitamin B₁₇: pseudoscientific name for the poisonous compound amygdalin, also known as the equally pseudoscientific name "nitrilosides" despite the fact that it is a single compound. Amygdalin can be found in various plants, but is most commonly extracted from apricot pits and other similar fruit kernels. Amygdalin is hydrolyzed by various intestinal enzymes to form, among other things, hydrogen cyanide, which is toxic to human beings when exposed to a high enough dosage. Some proponents claim that amygdalin is effective in cancer treatment and prevention, despite its toxicity and a severe lack of scientific evidence.
• Vitamin B₂₀: L-carnitine.
• Vitamin B_f: carnitine.
• Vitamin B_m: myo-inositol, also called "mouse antialopaecia factor".
• Vitamin B_p: "antiperosis factor", which prevents perosis, a leg disorder, in chicks; can be replaced by choline and manganese salts.
• Vitamin B_T: carnitine.
• Vitamin B_v: a type of B₆ other than pyridoxine.
• Vitamin B_W: a type of biotin other than d-biotin.
• Vitamin B_x: an alternative name for both pABA (see vitamin B₁₀) and pantothenic acid.

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References

Source of article : Wikipedia